Anticorps ANTI - MUS81 produit dans la souris, clone, immunoglobulin purifiée, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

MUS81 plays a vital role in the metabolism of replication intermediates. In mammals, MUS81 interacts with the non-catalytic subunits essential meiotic structure-specific endonuclease (EME) 1 or EME 2 to form heterodimer complexes. These complexes have the ability to cleave replication forks (RFs) in vitro. Downregulated expression of Mus81 enhances the sensitivity of colon cancer cells to chemotherapeutic drugs by inducing S phase arrest and apoptosis through CHK1 pathway activation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

MUS81 structure-specific endonuclease subunit is a DNA repair gene, mapped to human chromosome 11q13.1. The encoded protein belongs to the XPF/ ERCC4 (xeroderma pigmentosum, complementation group F) protein family.

Immunogen

MUS81 (NP_079404.2, 1 a.a. ~ 551 a.a) full-length human protein.SequenceMAAPVRLGRKRPLPACPNPLFVRWLTEWRDEATRSRHRTRFVFQKALRSLRRYPLPLRSGKEAKILQHFGDGLCRMLDERLQRHRTSGGDHAPDSPSGENSPAPQGRLAEVQDSSMPVPAQPKAGGSGSYWPARHSGARVILLVLYREHLNPNGHHFLTKEELLQRCAQKSPRVAPGSAPPWPALRSLLHRNLVLRTHQPARYSLTPEGLELAQKLAESEGLSLLNVGIGPKEPPGEETAVPGAASAELASEAGVQQQPLELRPGEYRVLLCVDIGETRGGGHRPELLRELQRLHVTHTVRKLHVGDFVWVAQETNPRDPANPGELVLDHIVERKRLDDLCSSIIDGRFREQKFRLKRCGLERRVYLVEEHGSVHNLSLPESTLLQAVTNTQVIDGFFVKRTADIKESAAYLALLTRGLQRLYQGHTLRSRPWGTPGNPESGAMTSPNPLCSLLTFSDFNAGAIKNKAQSVREVFARQLMQVRGVSGEKAAALVDRYSTPASLLAAYDACATPKEQETLLSTIKCGRLQRNLGPALSRTLSQLYCSYGPLT

Physical form

Solution in phosphate buffered saline, pH 7.4