Anti-EphB1 (récepteur ELK )- EXT anticorps produit en moutons, immunoglobulin purifié, solution aqueuse tamponnée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Anti- EphB1 (ELK Receptor)-EXT antibody may be used for immunoblotting at a working concentration of 1-10 µg/ml. Antibody concentration of 10-20 µg/ml is recommended for immunoprecipitation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Eph family of tyrosine kinase receptors mediates cell-cell attachment and aggregation by binding to specific ligands, ephrins. The Eph family consists of 14 structurally related receptors that are either membrane linked or are transmembrane with overlapping affinity for ligands. The transmembrane receptors EphA and EphB1 (ELK) subclasses signal via distinct mediators in the cytoplasm. EphB1 binds ephrinB1, recruits Grb2 and Grb10 and mediates cell attachment and cell-cell assembly. Activated EphB1 also reportedly mediates the signaling by c-Jun kinase. The EphB1 receptors are vital in targeting the migration of neurons, angiogenesis and vascular cell assembly during development Anti-EphB1 (Elk Receptor)-EXT recognizes the external region of human EphB1 protein (116 kDa).

Immunogen

GST-fusion protein EphB1 (Elk Receptor)-EXT corresponding to amino acids 16-351 of the N-terminal region.

Physical form

Solution in phosphate buffered saline with 0.08% sodium azide.