Anti-GAB1, C-Terminal antibody produced in rabbit, approx. 1 mg/mL, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-GAB1 antibody produced in rabbit has been used in proximity ligation assay (1:100) and western blotting.

Biochem/physiol Actions

GRB2 associated binding protein 1 (GAB1) acts as a scaffold protein for protein-protein interaction. It regulates growth factor receptors and enhances signal transduction of multiple intracellular signaling pathways, such as phosphatidylinositol 3-kinase and protein kinase B (PKB/AKT)/ mammalian target of rapamycin (mTOR) signaling pathways. Upregulated expression of GAB1 contributes to the progression of various types of cancer including human oral squamous cell carcinoma (OSCC), breast cancer, colorectal cancer, hepatocellular carcinoma, and ovarian cancer. Therefore, knockdown of the GAB1 gene can be considered as a potential therapeutic strategy for treating breast cancer and OSCC.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

The GRB2 associated binding protein 1 (GAB1) protein is encoded by the gene mapped to human chromosome 4q31.21. The encoded protein belongs to the Grb2-associated binding protein family. GAB1 protein structure contains pleckstrin homology domain and tyrosine residues. Anti-GAB1 Antibody detects endogenous levels of total GAB1 protein.

Anti-GAB1 Antibody detects endogenous levels of total GAB1 protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human GAB1. Immunogen Range: 644-674

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.