Anti-PTK2B (Ab-402) antibody produced in rabbit, affinity isolated antibody

Not available outside of the UK & Ireland.

Application

Anti-PTK2B (Ab-402) antibody has been used in immunohistofluorescence.

Biochem/physiol Actions

Protein tyrosine kinase 2β(PTK2B) participates in the pathogenesis of Alzheimer′s disease (AD). It induces tumor progression in multiple myeloma. It helps in the multiplication, movement and survival of cells.

Disclaimer

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Features and Benefits

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General description

PTK2B/ Pyk2 (proline-rich tyrosine kinase 2β) is a non receptor protein kinase that belongs to the focal adhesion kinase family. It is also known as FAK2 (focal adhesion kinase 2), RAFTK (related adhesion focal tyrosine kinase) and CAKB (cell adhesion kinase beta). Its expression is confined to the endothelium, central nervous system and hematopoietic lineages. It is located on human chromosome 8p21.1.

Immunogen

Peptide sequence around aa. 400-404 (D-I-Y-A-E), according to the protein PTK2B.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.