Anti-phospho-NBN (pSer343) antibody produced in rabbit, affinity isolated antibody

Not available outside of the UK & Ireland.

Features and Benefits

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Immunogen

Peptide sequence around phosphorylation site of serine 343 (S-L-S(p)-Q-G), according to the protein NBN.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.