Anti-phospho-STAT3 (pSer727) antibody produced in rabbit, affinity isolated antibody

Not available outside of the UK & Ireland.

Application

Anti-phospho-STAT3 (pSer727) antibody produced in rabbit has been used in immunoblotting (1:1000) and immunofluorescence staining (1:200).

Biochem/physiol Actions

Signal transducer and activator of transcription 3 (STAT3) protein play a key role in cell growth, apoptosis, metabolism, cellular respiration, and autophagy. It may act as a co-activator of signal transduction by glucocorticoid receptors. STAT3 regulates transcription. It is involved in the development of vertebrates and the regulation of inflammation and immunity. It might participate in airway inflammation, allergy, and asthma. Mutations in the STAT3 gene are associated with immunodeficiency, autoimmunity, and cancer.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Signal transducer and activator of transcription 3 (STAT3), a constituent of the interleukin-6- (IL-6) activated acute phase response factor (APRF) complex, belongs to the signal transducer and activator of transcription (STAT) family. It is expressed in all types of tissues. The STAT3 gene with 24 exons is mapped to human chromosome 17q21.2.

Immunogen

Peptide sequence around phosphorylation site of serine 727 (P-M-S(p)-P-R), according to the protein STAT3.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Target description

Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.