Anticorps Anti- SIGLEC15 produit dans un anticorps isolé rabbit affinity

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Sialic acid binding Ig like lectin 15 (SIGLEC15) recognizes a tumor-linked glycan structure called the sialyl-Tn (sTn) antigen. It is expressed on tumor-associated macrophages in tumor tissues. The protein acts as a signal transducer. SIGLEC15 associates with the adaptor protein DNAX activation protein of 12kDa (DAP12) and transduces a signal to spleen tyrosine kinase (Syk).

Disclaimer

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General description

Sialic acid binding Ig like lectin 15 (SIGLEC15) is part of the Siglec family of glycan-recognition proteins. It is expressed in a subset of macrophages. This type-I transmembrane protein possesses two immunoglobulin-like domains, a transmembrane domain and a short cytoplasmic tail. The SIGLEC15 gene is localized on human chromosome 18q12.3.

Immunogen

Antibody was raised against a 15 amino acid peptide near the amino terminus of human SIGLEC15.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500654.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.