Anti-APBA1/MINT1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution

Not available outside of the UK & Ireland.

Application

Anti-APBA1/MINT1 antibody produced in goat is suitable for indirect ELISA and western blot analysis.

Biochem/physiol Actions

APBA1 (Amyloid β (A4) precursor protein binding, family A, member 1) stabilizes amyloid precursor protein (APP) by directly interacting with it. It also restricts production as well as accumulation of proteolytic APP fragment in the brain of Alzheimer′s disease patients. It also suppresses glycogen synthase kinase-3β promoter activity by coupling with a silencer binding protein.

Features and Benefits

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General description

APBA1 (Amyloid β (A4) precursor protein binding, family A, member 1) is a neuronal adaptor protein belonging to the X11 family. It consists of a centrally located phosphotyrosine binding domain which inhibits the production of Aβ peptide, two C-terminal postsynaptic density-95, large discs, zona occludens 1 (PDZ) domains.

Immunogen

Peptide with sequence C-EASHPSQDGKRQYK from the internal region of the protein sequence according to NP_001154.2.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.