ANTI-CASPASE-1 (AB1)

Not available outside of the UK & Ireland.

Application

Anti-Caspase-1 (ab1) antibody produced in rabbit has been used in western blotting and immunofluorescence staining.

Biochem/physiol Actions

Caspase-1 can transform the pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18 into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients. It helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Caspase-1 is also known as interleukin-1β converting enzyme (ICE). It is located on chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. It is present in leukocytes, monocytes and epithelial cells.

Immunogen

a 16 amino acid peptide from near the carboxy-terminus of human Caspase-1.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3459.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide