Anti-Sh3Gl1

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

SH3GL1 (SH3-containing Grb2-like) is involved with oncogenic activity in case of primary malignant central nervous system tumor (gliomas) in adults. It effectively evokes an autogenic antibody reaction in low-grade gliomas. In comparison with normal breast epithelial cells, the SH3GL1 expression is high in many TNBCs (Triple-negative breast cancers cells). The mutational study of AIS (adolescent idiopathic scoliosis) patients with respect to SH3GL1 gene showed that it is one of the probable genes correlated with AIS disease.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways: IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. Protein array of 364 human recombinant protein fragments.

General description

The Src-homology-3 domain (SH3) of the protein SH3GL (SH3-containing Grb2-like) is a 50 to 60 amino-acid module. The C- terminal end contains SH3 domain and exhibits 56-50% amino acid analogy with SH3 of Sem-5/Drk/Grb2. The N-terminal of SH3GL is very unique in comparison with any known protein. SH3GL1 is ubiquitous in its expression. Gene coding for SH3GL protein is mapped to human chromosome 19p13.3.

Immunogen

Endophilin-A2 recombinant protein epitope signature tag (PrEST)

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Linkage

Corresponding Antigen APREST74808.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide