Monoclonal Anti-Cdk7/CAK antibody produced in mouse, clone MO-1.1, ascites fluid

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Monoclonal Anti-Cdk7/CAK antibody produced in mouse is suitable for the following applications: Immunocytochemistry Immunohistochemistry (frozen sections) Immunoprecipitation Microarray Western blotting at a dilution of 1:50,000 using a cultured human cell line extract

Biochem/physiol Actions

Cyclin-dependent kinase (CDK) Activating Kinase (CAK) is involved in activation and phosphorylation of CDK1, CDK2, CDK4 and CDK6 and regulation of the cell cycle. It is required for cell cycle progression and it could be a target for cancer therapy. CAK plays a central role in regulation of messenger RNA synthesis by either inhibition of RNA polymerase II-catalyzed transcription or stimulation of transcription through association with basal transcription repair factor IIH. Phosphorylation by the CDK-activating kinase (CAK) is required for the activation of cyclin-dependent kinases.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Cell division protein kinase 7 is an enzymes encoded by the CDK7 gene in humans. The protein belongs to cyclin-dependent protein kinase (CDK) family. CAK is a CDK-cyclin complex implicated in the control of multiple cell cycle transitions. The structure of CDK7 facilitates the inhibitors with differential specificity for the different CDKs and can be used in different biological processes.

Immunogen

recombinant human Cdk7 protein.

Specificity

The antibody reacts specifically with Cdk7 (40 kDa catalytic subunit of Cdk activating kinase).