Cardiac Troponin I 10ug

Not available outside of the UK & Ireland.

Application

Ubiquitination Cascade Comoponent: Substrate

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Troponin is a complex of three regulatory proteins (Troponin I, Troponin T and Troponin C). It is located on the actin filament and is essential for the calcium-mediated regulation of skeletal and cardiac muscle contraction. There are tissue-specific isoforms of Troponin I, T and C and two subtypes (Cardiac Troponin I and T) are released when the heart muscle has been damaged, such as during a heart attack. The more damage there is to the heart, the greater the amount of Troponin I and T there will be in the blood and currently, Cardiac Troponin I and T are used as the preferred biochemical markers for the diagnosis of myocardial infarction. It has also been demonstrated that Cardiac Troponin I is targeted for degradation by MuRF1, an E3 ubiquitin ligase that has been linked to muscle atrophy

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

Purified using immobilized metal affinity chromatography.