SEL DE TRIFLUOROACÉTATE GAP19

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

Gap19 trifluoroacetate salt has been used to inhibit Ca²⁺/calmodulin (CaM) gating response of connexin 43 (Cx43) gap junctions.

Biochem/physiol Actions

Gap19, nonapeptide from the cytoplasmic loop of Connexin-43, is a selective blocker of connexin 43 (Cx43) hemichannel that does not block GJ or Cx40/Panx-1 channels in cardiomyocytes and astrocytes. Gap19 prevents Cx43 hemichannel opening and protect against myocardial ischemia/reperfusion injury.

Packaging

1 mg in glass bottle