NU6140

Code: sml1323-5mg D2-231

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

NU6140 has been used to study its effect on transcription factors NANOG, OCT4 (organic cation/carnitine transporter 4) and SOX2(SRY-box 2), involved in pluripoten...


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Votre prix
$129.77 5MG
DEMANDER

Non disponible en dehors du Royaume-Uni et de l'Irlande

Application

NU6140 has been used to study its effect on transcription factors NANOG, OCT4 (organic cation/carnitine transporter 4) and SOX2(SRY-box 2), involved in pluripotency of human embryonic stem (hES) cells and embryonal carcinoma-derived (hEC) cells.

Biochem/physiol Actions

NU6140 is a CDK2 inhibitor with 10-36-fold selectivity over other CDK family members. NU6140 induces apoptosis and cell cycle arrest in cancer cells in the G2-M phase, and potentiates the cytotoxic effects of paclitaxel.

NU6140 is known to downregulate the expression of survivin protein, which possesses antiapoptotic activity and is generally overexpressed in cancer cells.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyXHEQSRJCJTWWAH-UHFFFAOYSA-N
InChI1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28)
Quality Level100
SMILES stringO=C(N(CC)CC)C1=CC=C(NC2=NC(NC=N3)=C3C(OCC4CCCCC4)=N2)C=C1
solubilityDMSO: 20 mg/mL, clear
storage temp.2-8°C
Cas Number444723-13-1
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :



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