Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Primary TargetNMDA receptors
Target IC50: 0.8, 0.57, 0.52, and 0.54 →M for GluN2A, B, C, and D, respectively.
General description
Memantine Hydrochloride is a very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors.
A very potent, voltage-dependent, rapidly unbinding antagonist (calcium channel blocker) of NMDA receptors (IC50 = 0.8, 0.57, 0.52, and 0.54 µM for GluN2A, B, C, and D, respectively). A popular medicine for treating moderate-to-severe Alzheimer′s disease. Frequently used in studying brain functions and disorders involving neurotransmission mediated by NMDA receptors (i.e. learning and memory, cognitive functions, neuroplasticity, Alzheimer′s disease, schizophrenia, bipolar depression, obsessive-compulsive disorders, oxidative stress, and excitotoxicity).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Limapichat, W., et al. 2012. ACS Chem. Neurosci.4, 255.Anand, A., et al. 2012. Bipolar Dis.14, 64.Lopes, P., et al. 2013. Brain and Behavior.3, 67.Howard, R., et al. 2012. New Eng. J. Med.366, 893.Parsons, G., et al. 1999. Neuropharmacol.38, 735. Lee, G., et al. 2012. Psychiatry Investig.9, 166.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Standard Handling (A)
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