MG-115

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Cell permeable: no

Reversible: yes

Product does not compete with ATP.

Target K_i: 21 nM and 35 nM for 20S and 26S proteasome, respectively

Primary Target20S proteasome

General description

Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively).

Potent reversible proteasome inhibitor (K_i = 21 nM and 35 nM for 20S and 26S proteasome, respectively). Specifically inhibits the chymotrypsin-like activity of the proteasome and induces apoptosis in Rat-1 and PC12 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Lopes, U.G., et al. 1997. J. Biol. Chem. 272, 12893.Lee, D.H., and Goldberg, A.L. 1996. J. Biol. Chem.271, 27280.Palombella, V.J., et al. 1994. Cell 78, 773. Rock, K.L., et al. 1994. Cell 78, 761.Vinitsky, A., et al. 1992. Biochemistry 31, 9421.

Packaging

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

Z-Leu-Leu-Nva-CHO

Warning

Toxicity: Standard Handling (A)