Non disponible en dehors du Royaume-Uni et de l'Irlande
Biochem/physiol Actions
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary TargetPTEN
General description
A potent phosphotyrosine phosphatase inhibitor. Activates the insulin receptor kinase (IRK) of hepatoma cells. Also stimulates lipogenesis in isolated adipocytes. Also reported to potently inhibit PTEN (IC50 = 14 nM).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Schmid, A.C., et al. 2004. FEBS Lett.566, 35.Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
Packaging
Packaged under inert gas
5 mg in Plastic ampoule
Reconstitution
Unstable in solution; reconstitute just prior to use.
Warning
Toxicity: Standard Handling (A)
Ce produit répond aux critères suivants pour être admissible aux récompenses suivantes :