alpha-synucleine E46K humain, recombinant, exprimé en E. coli, N-terminal histidine étiqueté, >=90% (SDS - PAGE) , poudre lyophilisée

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Among the familial mutations of α-synuclein in Parkinson′s disease, E46K has the greatest potential to aggregate. This mutation is a 188G-A tran­sition resulting in a Glu⁴⁶-to-Lys (E46K) substitution in the amino-terminal region of the protein.

Deposition of α-synuclein as fibrillary tangles is a hallmark of certain neurodegenerative diseases including Parkinson′s. Among the familial mutations of α-synuclein, E46K has the greatest potential to aggregate.