Inhibiteur de déacetylase Histone III

Non disponible en dehors du Royaume-Uni et de l'Irlande

Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Target IC₅₀: 40 nM for rat liver HDAC

Primary TargetRat liver HDAC

Cell permeable: yes

General description

A cell-permeable, amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylase (IC₅₀ = 40 nM for rat liver HDAC and IC₅₀ = 100 nM for maize HDAC). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.

A cell-permeable amide analog of Trichostatin A (Cat. No. 647925) that potently inhibits histone deacetylases (IC₅₀ = 40 nM for rat liver HDAC and IC₅₀ = 100 nM for maize HD). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ramiszewski, S.W., et al. 2002. J. Med. Chem.45, 753.Jung, M., et al. 1999. J. Med. Chem.42, 4669.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)